Time Series, Health & Evidence Synthesis · Clinical Research & Protocols

Clinical trial design — Theory and advanced biostatistics

Public introduction · full guide in Eikos

Introduction

What this guide covers

An expert-level methodological and biostatistical reference guide for the planning, mathematical modeling and analysis of therapeutic clinical interventions.

Overview

Topics covered

  • Introduction
  • Clinical Trial Design
  • Taxonomy and Phases of Clinical Trials
  • Clinical Development Phases
  • Phase I: Human Pharmacology and Initial Safety
  • Phase II: Biological Activity and Proof of Concept

Related concepts

Main connections

  • Clinical trials & RCT design
  • Permutation & exact tests
  • Calculus & differentiation
  • Survival analysis & Kaplan-Meier
  • p-value & significance
  • Hypothesis testing

Compatible notation

Mathematical sample in LaTeX

The expression is rendered accessibly, with its LaTeX source preserved below.

ForM=4,The possible balanced permutations are:{AABB,ABAB,ABBA,BBAA,BABA,BAAB}
View LaTeX source\text{For} M=4, \text{The possible balanced permutations are:} \{AABB, ABAB, ABBA, BBAA, BABA, BAAB\}